LUMC – Leiden, NL

The LUMC group has long-standing expertise in conducting clinical, epidemiological, genetic, and experimental migraine research at the Departments of Neurology & Human Genetics. They identified the first migraine gene in a rare familial migraine subtype (and several genes for other migraine related diseases), have generated and characterised the first transgenic translational mouse models, and were at the forefront of the identification of genes for common forms of migraine. Using their efficient webbased patient recruiting approach, LUMINA, they collected already > 4000 migraine patients and DNA (> 3000), and from hundreds cerebrospinal fluid that is complemented with neuroimaging data.

LUMC website: Neurology
LUMC website: Human Genetics
LUMC patient recruitment: Lumina

Involvement

  • Project coordinator
  • Leader of WP3, WP6, and WP7
  • Participant in WP1 and WP4.

Key Personnel

Michel D. Ferrari, MD, PhD, is Professor of Neurology and heads the Leiden Centre for Translational Neuroscience, the migraine clinical group, and is former leader of FP6 EUROHEAD.

Arn M.J.M. van den Maagdenberg, PhD, is Professor of Molecular and Functional Neurogenetics is an expert in translational mouse models with much experience in EU projects.

Gisela M. Terwindt, MD, PhD, is Associate Professor and heads the Neurology outpatient clinic.

Else A. Tolner, PhD, is Postdoctoral fellow in charge of neuro/electrophysiological studies in transgenic mice.