Publications

Publications originating from the EUROHEADPAIN project

2017 – Epub ahead of print

Bauer PR, Thijs RD, Lamberts RJ, Velis DN, Visser GH, Tolner EA, Sander JW, Lopes da Silva FH, Kalitzin SN.
Dynamics of convulsive seizure termination and postictal generalized EEG suppression.
Brain, Jan 10, 2017. [Epub ahead of print]

Chauvel V, Multon S, Schoenen J.
Estrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: Modelling the serotonin-ovarian hormone interaction in migraine aura. Cephalalgia, Jan 1, 2017. [Epub ahead of print]

Dux M, Will C, Eberhardt M, Fischer MJ, Messlinger K.
Stimulation of rat cranial dura mater with potassium chloride causes CGRP release into the cerebrospinal fluid and increases medullary blood flow.
Neuropeptides, Feb 10, 2017. [Epub ahead of print]

Gerring ZF, Powell JE, Montgomery GW, Nyholt DR.
Genome-wide analysis of blood gene expression in migraine implicates immune-inflammatory pathways.
Cephalalgia,  Jan 1, 2017. [Epub ahead of print]

Schulte LH, May A.
Of generators, networks and migraine attacks.
Curr Opin Neurol, Feb 24, 2017. [Epub ahead of print]

Winsvold BS, Palta P, Eising E, Page CM; International Headache Genetics Consortium, van den Maagdenberg AM, Palotie A, Zwart JA.
Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study.
Cephalalgia, Jan 1, 2017. [Epub ahead of print]

2017

van Dongen RM, Zielman R, Noga M, Dekkers OM, Hankemeier T, van den Maagdenberg AM, Terwindt GM, Ferrari MD.
Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis.
Cephalalgia 37:49-63, 2017.

Eising E, Pelzer N, Vijfhuizen LS, Vries B, Ferrari MD, ‘t Hoen PA, Terwindt GM, van den Maagdenberg AM.
Identifying a gene expression signature of cluster headache in blood.
Sci Rep 7: 40218, 2017.

Goadsby PJ, Holland PR, Martins-Oliveira M, Hoffmann J, Schankin C, Akerman S.
Pathophysiology of migraine: A disorder of sensory processing.
Physiol Rev 97: 553-622, 2017.

Guo S, Christensen AF, Liu ML, Janjooa BN, Olesen J, Ashina M.
Calcitonin gene-related peptide induced migraine attacks in patients with and without familial aggregation of migraine.
Cephalalgia 37: 114-124, 2017.

Guo S, Vollesen AL, Hansen RD, Esserlind AL, Amin FM, Christensen AF, Olesen J, Ashina M.
Part I: Pituitary adenylate cyclase-activating polypeptide-38 induced migraine-like attacks in patients with and without familial aggregation of migraine.
Cephalalgia 37:125-135, 2017.

Guo S, Vollesen AL, Hansen YB, Frandsen E, Andersen MR, Amin FM, Fahrenkrug J, Olesen J, Ashina M.
Part II: Biochemical changes after pituitary adenylate cyclase-activating polypeptide-38 infusion in migraine patients.
Cephalalgia 37: 136-147, 2017.

Guo S, Vollesen AL, Olesen J, Ashina M.
Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine.
Pain 157: 2773-2781, 2016.

Hansen EK, Olesen J.
Towards a pragmatic human migraine model for drug testing: 2. Isosorbide-5-mononitrate in healthy individuals.
Cephalalgia 37: 136-147, 2017.

Kantae V, Ogino S, Noga M, Harms AC, van Dongen RM, Onderwater GL, van den Maagdenberg AM, Terwindt GM, van der Stelt M, Ferrari MD, Hankemeier T. Quantitative profiling of endocannabinoids and related N-acylethanolamines in human CSF using nano LC-MS/MS.
J Lipid Res 58: 615-624, 2017.

Khan S, Amin FM, Holtmannspötter M, Hansen K, Florescu AM, Fakhril-Din Z, Petersen JF, Ghanizada H, Ayata C, Gaist D, Ashina M.
Endovascular thrombectomy and post-procedural headache.
J Headache Pain 18: 10, 2017..

Knapp L, Szita B, Kocsis K, Vécsei L, Toldi J.
Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues.
Drug Des Devel Ther 11: 27-34, 2017.

Martins-Oliveira M, Akerman S, Holland PR, Hoffmann JR, Tavares I, Goadsby PJ.
Neuroendocrine signaling modulates specific neural networks relevant to migraine.
Neurobiol Dis 101:16-26, 2017.

Mehnert J, Schulte L, Timmann D, May A.
Activity and connectivity of the cerebellum in trigeminal nociception.
Neuroimage 150: 112-118, 2017.

Mulder IA, Khmelinskii A, Dzyubachyk O, de Jong S, Rieff N, Wermer MJ, Hoehn M, Lelieveldt BP, van den Maagdenberg AM.
Automated ischemic lesion segmentation in MRI mouse brain data after transient middle cerebral artery occlusion.
Front Neuroinform 11: 3, 2017.

Veres G, Fejes-Szabó A, Zádori D, Nagy-Grócz G, László AM, Bajtai A, Mándity I, Szentirmai M, Bohár Z, Laborc K, Szatmári I, Fülöp F, Vécsei L, Párdutz Á.
A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study. J Neural Transm 124: 99-112, 2017.

2016 – Epub ahead of print

Ambrosini A, Coppola G, Iezzi E, Pierelli F, Schoenen J.
Reliability and repeatability of testing visual evoked potential habituation in migraine: A blinded case-control study.
Cephalalgia, May 6, 2016. [Epub ahead of print]

Ashina H, Schytz HW, Ashina M.
CGRP in human models of primary headaches.
Cephalalgia, Dec 2016 [Epub ahead of print]

Britze J, Arngrim N, Schytz HW, Ashina M.
Hypoxic mechanisms in primary headaches.
Cephalalgia, May 4, 2016. [Epub ahead of print]

Eising E, Shyti R, ‘t Hoen PA,, Huisman SM, Broos LA, Mahfouz A, Reinders MJ, Ferrari MD, Tolner EA, de Vries B, van den Maagdenberg AM.
Cortical spreading depression causes unique dysregulation of inflammatory pathways in a transgenic mouse model of migraine.
Mol Neurobio, Mar 31, 2016. [Epub ahead of print]

Herédi J, Berkó AM, Jankovics F, Iwamori T, Iwamori N, Ono E, Horváth S, Kis Z, Toldi J, Vécsei L, Gellért L.
Astrocytic and neuronal localization of kynurenine aminotransferase-2 in the adult mouse brain.
Brain Struct Funct, Aug 2016 [Epub ahead of print]

Houben T, Loonen IC, Baca SM, Schenke M, Meijer JH, Ferrari MD, Terwindt GM, Voskuyl RA, Charles A, van den Maagdenberg AM, Tolner EA.
Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice.
J Cereb Blood Flow Metab, Jul 27, 2016. [Epub ahead of print]

Lisicki M, Ruiz-Romagnoli E, D’Ostilio K, Piedrabuena R, Giobellina R, Schoenen J, Magis D.
Familial history of migraine influences habituation of visual evoked potentials.
Cephalalgia, Nov 2016 [Epub ahead of print]

Magis D, D’Ostilio K, Thibaut A, De Pasqua V, Gerard P, Hustinx R, Laureys S, Schoenen J.
Cerebral metabolism before and after external trigeminal nerve stimulation in episodic migraine.
Cephalalgia, Aug 31, 2016. [Epub ahead of print]

Mulder IA, Esteve C, Wermer M, Hoehn M, Tolner EA, van den Maagdenberg AM, McDonnell LA.
Funnel-freezing versus heat-stabilisation for the visualization of metabolites by mass spectrometry imaging in a mouse stroke model.
Proteomics, Mar 9, 2016. [Epub ahead of print]

Pelzer N, Blom DE, Stam AH, Vijfhuizen LS, Hageman A, van Vliet JA, Ferrari MD, van den Maagdenberg A, Haan J, Terwindt GM.
Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation.
Cephalalgia, May 24, 2016. [Epub ahead of print]

Schoenen J, Roberta B, Magis D, Coppola G.
Noninvasive neurostimulation methods for migraine therapy: The available evidence.
Cephalalgia, Mar 29, 2016. [Epub ahead of print]

Segelcke D, Messlinger K.
Putative role of 5-HT2B receptors in migraine pathophysiology.
Cephalalgia, Apr 28, 2016. [Epub ahead of print]

Stam AH, Kothari PH, Shaikh A, Gschwendter A, Jen JC, Hodgkinson S, Hardy TA, Hayes M, Kempster PA, Kotschet KE, Bajema IM, van Duinen SG, Maat-Schieman ML, de Jong PT, de Smet MD, de Wolff-Rouendaal D, Dijkman G, Pelzer N, Kolar GR, Schmidt RE, Lacey J, Joseph D, Fintak DR, Grand MG, Brunt EM, Liapis H, Hajj-Ali RA, Kruit MC, van Buchem MA, Dichgans M, Frants RR, van den Maagdenberg AM, Haan J, Baloh RW, Atkinson JP, Terwindt GM, Ferrari MD.
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.
Brain. Sep 19, 2016. [Epub ahead of print]

Vollesen AL, Guo S, Ashina M.
PACAP38 dose-response pilot study in migraine patients.
Cephalalgia, Apr 15, 2016. [Epub ahead of print]

Yin P, Anttila V, Siewert KM, Palotie A, Smith GD, Voight BF.
Serum calcium and risk of migraine: a Mendelian randomization study.
Hum Mol Genet, Dec 2016. [Epub ahead of print]

2016

Arngrim N, Schytz HW, Britze J, Amin FM, Vestergaard MB, Hougaard A, Wolfram F, de Koning PJ, Olsen KS, Secher NH, Larsson HB, Olesen J, Ashina M.
Migraine induced by hypoxia: a MRI spectroscopy and angiography study.
Brain 139: 723-737, 2016.

Bohár Z, Párdutz Á, Vécsei L.
Tryptophan Catabolites and Migraine.
Curr Pharm Des 22: 1013-1021, 2016.

Chen SP, Tolner EA, Eikermann-Haerter K.
Animal models of monogenic migraine.
Cephalalgia 36: 704-721, 2016.

de Coo IF, Wilbrink LA, Haan J, Ferrari MD, Terwindt GM.
Evaluation of the new ICHD-III beta cluster headache criteria.
Cephalalgia 36: 547-551, 2016.

Coppola G, Di Renzo A, Tinelli E, Lepre C, Di Lorenzo C, Di Lorenzo G, Scapeccia M, Parisi V, Serrao M, Colonnese C, Schoenen J, Pierelli F.
Thalamo-cortical network activity between migraine attacks: Insights from MRI-based microstructural and functional resting-state network correlation analysis.
J Headache Pain 17: 100, 2016.

Dal Ben D, Marchenkova A, Thomas A, Lambertucci C, Spinaci A, Marucci G, Nistri A, Volpini R.
2′,3′-O-Substituted ATP derivatives as potent antagonists of purinergic P2X3 receptors and potential analgesic agents.
Purinergic Signal 13: 61-74, 2016.

Dux M, Will C, Vogler B, Filipovic MR, Messlinger K.
Meningeal blood flow is controlled by H2 S-NO crosstalk activating HNO-TRPA1-CGRP signalling.
Br J Pharmacol 173: 431-445, 2016.

Eising E, Huisman SM, Mahfouz A, Vijfhuizen LS, Anttila V, Winsvold BS, Kurth T, Ikram MA, Freilinger T, Kaprio J, Boomsma DI, van Duijn CM, Järvelin MR, Zwart JA, Quaye L, Strachan DP, Kubisch C, Dichgans M, Davey Smith G, Stefansson K, Palotie A, Chasman DI, Ferrari MD, Terwindt GM, de Vries B, Nyholt DR, Lelieveldt BP, van den Maagdenberg AM, Reinders MJ.
Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas.
Hum Genet 135: 425-439, 2016.

Eising E, de Leeuw C, Min JL, Anttila V, Verheijen MH, Terwindt GM, Dichgans M, Freilinger T, Kubisch C; International Headache Genetics Consortium, Ferrari MD, Smit AB, de Vries B, Palotie A, van den Maagdenberg AM, Posthuma D.
Involvement of astrocyte and oligodendrocyte gene sets in migraine.
Cephalalgia 36: 640-647, 2016.

Esteve C, Tolner EA, Shyti R, van den Maagdenberg AM, McDonnell LA.
Mass spectrometry imaging of amino neurotransmitters: a comparison of derivatization methods and application in mouse brain tissue.
Metabolomics 12: 30, 2016.

Gerring Z, Rodriguez-Acevedo AJ, Powell JE, Griffiths LR, Montgomery GW, Nyholt DR.
Blood gene expression studies in migraine: Potential and caveats.
Cephalalgia 36: 669-678, 2016.

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A, McMahon G, Ligthart L, Terwindt GM, Kallela M, Freilinger TM, Ran C, Gordon SG, Stam AH, Steinberg S, Borck G, Koiranen M, Quaye L, Adams HH, Lehtimäki T, Sarin AP, Wedenoja J, Hinds DA, Buring JE, Schürks M, Ridker PM, Hrafnsdottir MG, Stefansson H, Ring SM, Hottenga JJ, Penninx BW, Färkkilä M, Artto V, Kaunisto M, Vepsäläinen S, Malik R, Heath AC, Madden PA, Martin NG, Montgomery GW, Kurki MI, Kals M, Mägi R, Pärn K, Hämäläinen E, Huang H, Byrnes AE, Franke L, Huang J, Stergiakouli E, Lee PH, Sandor C, Webber C, Cader Z, Muller-Myhsok B, Schreiber S, Meitinger T, Eriksson JG, Salomaa V, Heikkilä K, Loehrer E, Uitterlinden AG, Hofman A, van Duijn CM, Cherkas L, Pedersen LM, Stubhaug A, Nielsen CS, Männikkö M, Mihailov E, Milani L, Göbel H, Esserlind AL, Christensen AF, Hansen TF, Werge T; International Headache Genetics Consortium, Kaprio J, Aromaa AJ, Raitakari O, Ikram MA, Spector T, Järvelin MR, Metspalu A, Kubisch C, Strachan DP, Ferrari MD, Belin AC, Dichgans M, Wessman M, van den Maagdenberg AM, Zwart JA, Boomsma DI, Smith GD, Stefansson K, Eriksson N, Daly MJ, Neale BM, Olesen J, Chasman DI, Nyholt DR, Palotie A.
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
Nat Genet 48: 856-866, 2016.

Guo S, Esserlind AL, Andersson Z, Frederiksen AL, Olesen J, Vissing J, Ashina M.
Prevalence of migraine in persons with the 3243A>G mutation in mitochondrial DNA.
Eur J Neurol 23: 175-181, 2016.

Hansen EK, Olesen J.
Towards a pragmatic human migraine model for drug testing: 2. Isosorbide-5-mononitrate in healthy individuals.
Cephalalgia 36: 172-178, 2016.

Hougaard Pedersen S, Maretty L, Ramachandran R, Sibbesen JA, Yakimov V, Elgaard-Christensen R, Hansen TF, Krogh A, Olesen J, Jansen-Olesen I.
RNA sequencing of trigeminal ganglia in rattus norvegicus after glyceryl trinitrate infusion with relevance to migraine.
PLoS One 11: e0155039, 2016.

Khan S, Amin FM, Hauerberg J, Holtmannspötter M, Petersen JF, Fakhril-Din Z, Gaist D, Ashina M.
Post procedure headache in patients treated for neurovascular arteriovenous malformations and aneurysms using endovascular therapy.
J Headache Pain 17: 73, 2016.

Kocsis K, Frank R, Szabó J, Knapp L, Kis Z, Farkas T, Vécsei L, Toldi J.
Acetyl-l-carnitine restores synaptic transmission and enhances the inducibility of stable LTP after oxygen-glucose deprivation.
Neuroscience 332: 203-211, 2016.

Kröger IL, Menz MM,May A.
Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system.
Cephalagia 36: 790-799, 2016.

Louter MA, Pelzer N, de Boer I, Kuijvenhoven BE, van Oosterhout WP, van Zwet EW, Ferrari MD, Terwindt GM.
Prevalence of lifetime depression in a large hemiplegic migraine cohort.
Neurology 87: 2370-2374, 2016.

Louter MA, Wilbrink LA, Haan J, van Zwet EW, van Oosterhout WP, Zitman FG, Ferrari MD, Terwindt GM.
Cluster headache and depression.
Neurology 87: 1899-1906, 2016.

Luedtke K, Allers A, Schulte LH, May A.
Efficacy of interventions used by physiotherapists for patients with headache and migraine-systematic review and meta-analysis.
Cephalalgia 36: 474-492, 2016.

Lukács M, Warfvinge K, Kruse LS, Tajti J, Fülöp F, Toldi J, Vécsei L, Edvinsson L.
KYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1β in the rat trigeminal ganglion.
J Headache Pain 17: 64, 2016.

Maassen van den Brink A, Meijer J, Villalón CM, Ferrari MD.
Wiping out CGRP: Potential cardiovascular risks.
Trends Pharmacol Sci 37: 779-788, 2016.

Magis D, Lisicki M, Coppola G.
Highlights in migraine electrophysiology: are controversies just reflecting disease heterogeneity?
Curr Opin Neurol 29: 320-330, 2016.

Majláth Z, Török N, Toldi J, Vécsei L.
Memantine and kynurenic acid: Current neuropharmacological aspects.
Curr Neuropharmacol 14:200-209, 2016.

Marchenkova A, van den Maagdenberg AM, Nistri A.
Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1.
Neuroscience 7, 331: 197-205, 2016.

Marchenkova A, Vilotti S, Ntamati N, van den Maagdenberg AM, Nistri A.
Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine.
Mol Pain 12: 12, 2016.

Martins Oliveira M, Akerman S, Tavares I,Goadsby PJ.
Neuropeptide Y inhibits the trigeminovascular pathway through NPY Y1 receptor: implications for migraine.
Pain 157: 1666-1673, 2016.

May A, Schulte LH.
Chronic migraine: risk factors, mechanisms and treatment.
Nat Rev Neurol 12: 455-464, 2016.

Mulder IA, Esteve C, Wermer M, Hoehn M,Tolner EA, van den Maagdenberg AM, McDonnell LA. Funnel-freezing versus heat-stabilisation for the visualization of metabolites by mass spectrometry imaging in a mouse stroke model.
Proteomics 16: 1652-1659, 2016.

Nagy-Grócz G, Tar L, Bohár Z, Fejes-Szabó A, Laborc KF, Spekker E,Vécsei L, Párdutz Á.
The modulatory effect of anandamide on nitroglycerin-induced sensitization in the trigeminal system of the rat.
Cephalalgia 36: 849-861, 2016.

Nöbel M, Feistel S, Ellrich J, Messlinger K.
ATP-sensitive muscle afferents activate spinal trigeminal neurons with meningeal afferent input in rat – pathophysiological implications for tension-type headache.
J Headache Pain 17: 75, 2016.

Nyholt DR, van den Maagdenberg AM.
Genome-wide association studies in migraine: current state and route to follow.
Curr Opin Neurol 29: 302-308, 2016.

Olde Rikkert MG, Dakos V, Buchman TG, de Boer R, Glass L, Cramer AO, Levin S, van Nes E, Sugihara G, Ferrari MD, Tolner EA, van de Leemput I, Lagro J, Melis R, Scheffer M.
Slowing down of recovery as generic risk marker for acute severity transitions in chronic diseases.
Crit Care Med 44: 601-606, 2016.

van Oosterhout WP, van Someren EJ, Louter MA, Schoonman GG, Lammers GJ, Rijsman RM, Ferrari MD, Terwindt GM.
Restless legs syndrome in migraine patients: prevalence and severity.
Eur J of Neurology_June 2016

Pijpers JA, Louter MA, de Bruin ME, van Zwet EW, Zitman FG, Ferrari MD, Terwindt GM.
Detoxification in medication-overuse headache, a retrospective controlled follow-up study: Does care by a headache nurse lead to cure?
Cephalalgia 36: 122-130, 2016.

Schulte LHMay A.
The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks.
Brain 139: 1987-1993, 2016.

Schulte LH, Sprenger C, May A.
Physiological brainstem mechanisms of trigeminal nociception: An fMRI study at 3T.
Neuroimage 124: 518-524, 2016.

Schulte LH, May A.
Functional Neuroimaging in Migraine: Chances and Challenges.
Headache 56: 1474-1481, 2016.

Tajti J, Szok D, Csáti A, Vécsei L.
Prophylactic drug treatment of migraine in children and adolescents: An update.
Curr Pain Headache Rep 20: 1, 2016.

Török N, Majláth Z, Fülöp F, Toldi J, Vécsei L.
Brain aging and disorders of the central nervous system: Kynurenines and drug metabolism.
Curr Drug Metab 17: 412-429, 2016.

Tuka B, Szabó N, Tóth E, Kincses ZT, Párdutz Á, Szok D, Körtési T, Bagoly T, Helyes Z, Edvinsson L, Vécsei L, Tajti J.
Release of PACAP-38 in episodic cluster headache patients – an exploratory study.
J Headache Pain 17: 69, 2016.

Varga N, Csapó E, Majláth Z, Ilisz I, Krizbai IA, Wilhelm I, Knapp L, Toldi J, Vécsei L, Dékány I.
Targeting of the kynurenic acid across the blood-brain barrier by core-shell nanoparticles.
Eur J Pharm Sci 86: 67-74, 2016.

Vilotti S, Vana N, Van den Maagdenberg AM, Nistri A.
Expression and function of calcitonin gene-related peptide (CGRP) receptors in trigeminal ganglia of R192Q Cacna1a knock-in mice.
Neurosci Lett. 620: 104-110, 2016.

de Vries B, Anttila V, Freilinger T, Wessman M, Kaunisto MA, Kallela M, Artto V, Vijfhuizen LS, Göbel H, Dichgans M, Kubisch C, Ferrari MD, Palotie A, Terwindt GM, van den Maagdenberg AM; on behalf of the International Headache Genetics Consortium.
Systematic re-evaluation of genes from candidate gene association studies in migraine using a large genome-wide association data set.
Cephalalgia 36: 604-614, 2016.

de Vries PS, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, Tang W, Teumer A, Marioni RE, Grossmann V, Hottenga JJ, Trompet S, Müller-Nurasyid M, Zhao JH, Brody JA, Kleber ME, Guo X, Wang JJ, Auer PL, Attia JR, Yanek LR, Ahluwalia TS, Lahti J, Venturini C, Tanaka T, Bielak LF, Joshi PK, Rocanin-Arjo A, Kolcic I, Navarro P, Rose LM, Oldmeadow C, Riess H, Mazur J, Basu S, Goel A, Yang Q, Ghanbari M, Willemsen G, Rumley A, Fiorillo E, de Craen AJ, Grotevendt A, Scott R, Taylor KD, Delgado GE, Yao J, Kifley A, Kooperberg C, Qayyum R, Lopez LM, Berentzen TL, Räikkönen K, Mangino M, Bandinelli S, Peyser PA, Wild S, Trégouët DA, Wright AF, Marten J, Zemunik T, Morrison AC, Sennblad B, Tofler G, de Maat MP, de Geus EJ, Lowe GD, Zoledziewska M, Sattar N, Binder H, Völker U, Waldenberger M, Khaw KT, McKnight B, Huang J, Jenny NS, Holliday EG, Qi L, McEvoy MG, Becker DM, Starr JM, Sarin AP, Hysi PG, Hernandez DG, Jhun MA, Campbell H, Hamsten A, Rivadeneira F, McArdle WL, Slagboom PE, Zeller T, Koenig W, Psaty BM, Haritunians T, Liu J, Palotie A, Uitterlinden AG, Stott DJ, Hofman A, Franco OH, Polasek O, Rudan I, Morange PE, Wilson JF, Kardia SL, Ferrucci L, Spector TD, Eriksson JG, Hansen T, Deary IJ, Becker LC, Scott RJ, Mitchell P, März W, Wareham NJ, Peters A, Greinacher A, Wild PS, Jukema JW, Boomsma DI, Hayward C, Cucca F, Tracy R, Watkins H, Reiner AP, Folsom AR, Ridker PM, O’Donnell CJ, Smith NL, Strachan DP, Dehghan A.
A meta-analysis of 120,246 individuals identifies 18 new loci for fibrinogen concentration.
Hum Mol Genet 25: 358-370, 2016.

Will C, Messlinger K, Fischer MJ.
Vessel diameter measurements at the medullary brainstem in vivo as an index of trigeminal activity.
Brain Res 1632: 51-57, 2016.

Yang Y, Ligthart L,Terwindt GM, Boomsma DI, Rodriguez-Acevedo AJ, Nyholt DR.
Genetic epidemiology of migraine and depression.
Cephalalgia 36: 679-691, 2016.

Yang Y, Zhao H, Heath AC, Madden PA, Martin NG, Nyholt DR.
Familial aggregation of migraine and depression: Insights from a large Australian twin sample.
Twin Res Hum Genet 19: 312-321, 2016.

Yang Y, Zhao H, Heath AC, Madden PA, Martin NG, Nyholt DR.
Shared Genetic Factors Underlie Migraine and Depression.
Twin Res Hum Genet 19: 341-350, 2016.

Zádori D, Veres G, Szalárdy L, Klivényi P, Fülöp F, Toldi J,Vécsei L.
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
Expert Opin Ther Pat 26: 815-832, 2016.

Zhao H, Eising E, de Vries B, Vijfhuizen LS; International Headache Genetics Consortium, Anttila V, Winsvold BS, Kurth T, Stefansson H, Kallela M, Malik R, Stam AH, Ikram MA, Ligthart L, Freilinger T, Alexander M, Müller-Myhsok B, Schreiber S, Meitinger T, Aromas A, Eriksson JG, Boomsma DI, van Duijn CM, Zwart JA, Quaye L, Kubisch C, Dichgans M, Wessman M, Stefansson K, Chasman DI, Palotie A, Martin NG, Montgomery GW, Ferrari MD, Terwindt GM, van den Maagdenberg AM, Nyholt DR.
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.
Cephalalgia 36: 648-57, 2016.

Zielman R, Postma R, Verhoeven A, Bakels F, van Oosterhout WP, Meissner A, van den Maagdenberg AM, Terwindt GM, Mayboroda OA, Ferrari MD.
Metabolomic changes in CSF of migraine patients measured with 1H-NMR spectroscopy.
Mol Biosyst 12: 3674-3682, 2016.

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2015

Bohár Z, Nagy-Grócz G, Fejes-Szabó A, Tar L, László AM, Büki A, Szabadi N, Vraukó V, Vécsei L, Párdutz Á.
Diverse effects of Brilliant Blue G administration in models of trigeminal activation in the rat.
J Neural Transm 122: 1621-1631, 2015.

Carreira RJ, Shyti R, Balluff B, Abdelmoula WM, van Heiningen SH, van Zeijl RJ, Dijkstra J, Ferrari MD, Tolner EA, McDonnell LA, van den Maagdenberg AM.
Large-scale mass spectrometry imaging investigation of consequences of cortical spreading depression in a transgenic mouse model of migraine.
J Am Soc Mass Spectrom 26: 853-861, 2015.

Csapó E, Bogár F, Juhász Á, Sebők D, Szolomájer J, Tóth GK, Majláth Z, Vécsei L, Dékány I.
Determination of binding capacity and adsorption enthalpy between Human Glutamate Receptor (GluR1) peptide fragments and kynurenic acid by surface plasmon resonance experiments. Part 2: Interaction of GluR1270–300 with KYNA.
Colloids Surf B Biointerfaces 133: 66-72, 2015.

Dahlem MA, Kurths J, Ferrari MD, Aihara K, Scheffer M, May A.
Understanding migraine using dynamic network biomarkers.
Cephalalgia 35: 627-630, 2015.

Demirkan A, Henneman P, Verhoeven A, Dharuri H, Amin N, van Klinken JB, Karssen LC, de Vries B, Meissner A, Göraler S, van den Maagdenberg AM, Deelder AM, t Hoen PA, van Duijn CM, van Dijk KW.
Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.
PLoS Genet 11: e1004835, 2015.

Dilekoz E, Houben T, Eikermann-Haerter K, Balkaya M, Lenselink AM, Whalen MJ, Spijker S, Ferrari MD, van den Maagdenberg AM, Ayata C.
Migraine mutations impair hippocampal learning despite enhanced long-term potentiation.
J Neurosci 35: 3397-3402, 2015

Fejes-Szabo A, Bohar Z, Nagy-Grocz G, Vamos E, Tar L, Podor B, Tajti J, Toldi J, Vecsei L, Pardutz A.
Effect of probenecid on the pain-related behaviour and morphological markers in orofacial formalin test of the rat.
CNS Neurol Disord Drug Targets 14: 350-359, 2015.

Ferrari MD, Klever RR, Terwindt GM, Ayata C, van den Maagdenberg AM.
Migraine pathophysiology: lessons from mouse models and human genetics.
Lancet Neurol 14: 65-80, 2015.

Guo S, Goetze JP, Jeppesen JL, Burnett JC, Olesen J, Jansen-Olesen I, Ashina M.
Effect of natriuretic peptides on cerebral artery blood flow in healthy volunteers.
Peptides 74: 33-42, 2015.

Heijs B, Carreira RJ, Tolner EA, de Ru AH, van den Maagdenberg AM, van Veelen PA, McDonnell LA.
Comprehensive analysis of the mouse brain proteome sampled in mass spectrometry imaging.
Anal Chem 87: 1867-1875, 2015.

Kröger IL, May A.
Triptan-induced disruption of trigemino-cortical connectivity.
Neurology 84: 2124-2131, 2015.

Kros L, Eelkman Rooda OH, Spanke JK, Alva P, van Dongen MN, Karapatis A, Tolner EA, Strydis C, Davey N, Winkelman BH, Negrello M, Serdijn WA, Steuber V, van den Maagdenberg AM, De Zeeuw CI, Hoebeek FE.
Cerebellar output controls generalized spike-and-wave discharge occurrence.
Ann Neurol 77: 1027-1049, 2015.

Magis D.
Neuromodulation in migraine: state of the art and perspectives.
Expert Rev Med Devices 12:329-339, 2015.

Majláth Z, Vécsei L.
Stress and the kynurenine pathway.
Orv Hetil 156: 1402-1405, 2015.

Malik R, Freilinger T, Winsvold BS, Anttila V, Vander Heiden J, Traylor M, de Vries B, Holliday EG, Terwindt GM, Sturm J, Bis JC, Hopewell JC, Ferrari MD, Rannikmae K, Wessman M, Kallela M, Kubisch C, Fornage M, Meschia JF, Lehtimäki T, Sudlow C, Clarke R, Chasman DI, Mitchell BD, Maguire J, Kaprio J, Farrall M, Raitakari OT, Kurth T, Ikram MA, Reiner AP, Longstreth WT Jr, Rothwell PM, Strachan DP, Sharma P, Seshadri S, Quaye L, Cherkas L, Schürks M, Rosand J, Ligthart L, Boncoraglio GB, Davey Smith G, van Duijn CM, Stefansson K, Worrall BB, Nyholt DR, Markus HS, van den Maagdenberg AM, Cotsapas C, Zwart JA, Palotie A; International Headache Genetics Consortium, Dichgans M; METASTROKE Collaboration of the International Stroke Genetics Consortium.
Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants.
Neurology 84: 2132-2145, 2015.

Marchenkova A, Vilotti S, Fabbretti E, Nistri A.
Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization.
Mol Pain 11: 71, 2015.

Nyholt DR; for the International Headache Genetics Consortium:, Anttila V, Winsvold BS, Kurth T, Stefansson H, Kallela M, Malik R, Vries BD, Terwindt GM, Ikram MA, Stam AH, Ligthart L, Freilinger T, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Aromaa A, Eriksson JG, Kaprio J, Boomsma DI, van Duijn C, Raitakari O, Järvelin MR, Zwart JA, Quaye L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Chasman DI, Palotie A.
Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies.
Cephalalgia 35: 489-499, 2015.

Roqueiro D, Witteveen MJ, Anttila V, Terwindt GM, van den Maagdenberg AM, Borgwardt K. In silico phenotyping via co-training for improved phenotype prediction from genotype.
Bioinformatics 31: i303–i310, 2015.

van der Sar SA, Zielman R, Terwindt GM, van den Maagdenberg AM, Deelder AM, Mayboroda OA, Meissner A, Ferrari MD.
Ethanol contamination of cerebrospinal fluid during standardized sampling and its effect on (1)H-NMR metabolomics.
Anal Bioanal Chem 407: 4835-4839, 2015.

Schulte LH, Jürgens TP, May A.
Photo-, osmo- and phonophobia in the premonitory phase of migraine: mistaking symptoms for triggers?
J Headache Pain 16: 14, 2015.

Shyti R, Eikermann-Haerter K, van Heiningen SH, Meijer OC, Ayata C, Joëls M, Ferrari MD, van den Maagdenberg AM, Tolner EA.
Stress hormone corticosterone enhances susceptibility to cortical spreading depression in familial hemiplegic migraine type 1 mutant mice.
Exp Neurol 263: 214-220, 2015.

Shyti R, Kohler I, Schoenmaker B, Derks RJ, Ferrari MD, Tolner EA, Mayboroda OA, van den Maagdenberg AM.
Plasma metabolic profiling after cortical spreading depression in a transgenic mouse model of hemiplegic migraine by capillary electrophoresis – mass spectrometry.
Mol Biosyst 11: 1462-1471, 2015.

Szok D, Csáti A, Vécsei L, Tajti J.
Treatment of chronic migraine with onabotulinumtoxinA: Mode of action, efficacy and safety.
Toxins 7: 2659-2673, 2015.

Tajti J, Majláth Z, Szok D, Csáti A, Vécsei L.
Drug safety in acute migraine treatment.
Expert Opin Drug Saf 14: 891-909, 2015.

Tajti J, Szok D, Majláth Z, Tuka B, Csáti A, Vécsei L.
Migraine and neuropeptides.
Neuropeptides 52: 19-30, 2015. [Acknowledgement in on-line version]

Tajti J, Tuka B, Botz B, Helyes Z, Vecsei L.
Role of pituitary adenylate cyclase-activating polypeptide in nociception and migraine.
CNS Neurol Disord Drug Targets 14: 540-553, 2015.

Tolner EA, Houben T, Terwindt GM, de Vries B, Ferrari MD, van den Maagdenberg AM.
From migraine genes to mechanisms.
Pain 156: S64-S74, 2015.

Varga D, Herédi J, Kánvási Z, Ruszka M, Kis Z, Ono E, Iwamori N, Iwamori T, Takakuwa H, Vécsei L, Toldi J, Gellért L.
Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice.
Front Behav Neurosci 9: 1-11, 2015.

Vécsei L, Majláth Z, Szok D, Csáti A, Tajti J.
Drug safety and tolerability in prophylactic migraine treatment.
Expert Opin Drug Saf 15: 1-19, 2015.

Vécsei L, Szok D, Csáti A, Tajti J.
CGRP antagonists and antibodies for the treatment of migraine.
Expert Opin Investig Drugs 24: 31-41, 2015.

Weller CM, Leen WG, Neville BG, Duncan JS, de Vries B, Geilenkirchen MA, Haan J, Kamsteeg EJ, Ferrari MD, van den Maagdenberg AM, Willemsen MA, Scheffer H, Terwindt GM.
A novel SLC2A1 mutation linking hemiplegic migraine with alternating hemiplegia of childhood.
Cephalalgia 35: 10-15, 2015.

Weller CM, Wilbrink LA, Houwing-Duistermaat JJ, Koelewijn SC, Vijfhuizen LS, Haan J, Ferrari MD, Terwindt GM, van den Maagdenberg AM, de Vries B.
Cluster headache and the hypocretin recepter 2 reconsidered: A genetic association study and meta-analysis.
Cephalalgia 35: 741-747, 2015.

Wild V, Messlinger K, Fischer M.
Hydrogen sulfide determines HNO-induced stimulation of trigeminal afferents.
Neurosci Lett 602: 104-109, 2015.

Winsvold BS, Nelson CP, Malik R, Gormley P, Anttila V, van der Heiden J, Elliott KS, Jacobsen LM, Palta P, Amin N, de Vries B, Hämäläinen E, Freilinger T, Ikram MA, Kessler T, Koiranen M, Ligthart L, McMahon G, Pedersen LM, Willenborg C, Won HH, Olesen J, Artto V, Assimes TL, Blankenberg S, Boomsma DI, Cherkas L, Davey Smith G, Epstein SE, Erdmann J, Ferrari MD, Göbel H, Hall AS, Jarvelin MR, Kallela M, Kaprio J, Kathiresan S, Lehtimäki T, McPherson R, März W, Nyholt DR, O’Donnell CJ, Quaye L, Rader DJ, Raitakari O, Roberts R, Schunkert H, Schürks M, Stewart AF, Terwindt GM, Thorsteinsdottir U, van den Maagdenberg AM, van Duijn C, Wessman M, Kurth T, Kubisch C, Dichgans M, Chasman DI, Cotsapas C, Zwart JA, Samani NJ, Palotie A; CARDIoGRAM Consortium and the International Headache Genetics Consortium.
Genetic analysis for a shared biological basis between migraine and coronary artery disease.
Neurol Genet 1: e10, 2015.

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2014

Abdelmoula WM, Škrášková K, Balluff B, Carreira RJ, Tolner EA, Lelieveldt BP, van der Maaten L, Morreau H, van den Maagdenberg AM, Heeren RM, McDonnell LA, Dijkstra J.
Automatic generic registration of mass spectrometry imaging data to histology using nonlinear stochastic embedding
.
Anal Chem 86: 9204-9211, 2014.

Eberhardt M, Dux M, Namer B, Miljkovic J, Cordasic N, Will C, Kichko TI, de la Roche J, Fischer M, Suárez SA, Bikiel D, Dorsch K, Leffler A, Babes A, Lampert A, Lennerz JK, Jacobi J, Martí MA, Doctorovich F, Högestätt ED, Zygmunt PM, Ivanovic-Burmazovic I, Messlinger K, Reeh P, Filipovic MR.
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.
Nat Commun 5: 4381, 2014.

Guo S, Barringer F, Zois NE, Goetze JP, Ashina M.
Natriuretic peptides and cerebral hemodynamics.
Regul Pep 192-193: 15-23, 2014.

Guo S, Olesen J, Ashina M.
Phosphodiesterase 3 inhibitor cilostazol induces migraine-like attacks via cyclic AMP increase.
Brain 137: 2951-2959, 2014.

Hullugundi SK, Ansuini A, Ferrari MD, van den Maagdenberg AM, Nistri A.
Hyperexcitability phenotype in mouse trigeminal sensory neurons expressing the r192q cacna1a missense mutation of familial hemiplegic migraine type-1.
Neuroscience 266: 244-254, 2014.

Jürgens TP, Schulte LH, May A.
Migraine trait symptoms in migraine with and without aura.
Neurology 82: 1416-1424, 2014.

Schueler M, Neuhuber WL, De Col R, Messlinger K.
Innervation of rat and human dura mater and pericranial tissues in the parieto-temporal region by meningeal afferents.
Headache 54: 996-1009, 2014.

Tajti J, Csáti A, Vécsei L.
Novel strategies for the treatment of migraine attacks via the CGRP, serotonin, dopamine, PAC1, and NMDA receptors.
Expert Opin Drug Metab Toxicol 10: 1509-1520, 2014.

Uebner M, Carr RW, Messlinger K, De Col R.
Activity-dependent sensory signal processing in mechanically responsive slowly conducting meningeal afferents.
J Neurophysiol 112: 3077-3085, 2014.

Zador F, Samavati R, Szlavicz E, Tuka B, Bojnik E, Fulop F, Toldi J, Vecsei L, Borsodi A.
Inhibition of opioid receptor mediated G-protein activity after chronic administration of kynurenic acid and its derivative without direct binding to opioid receptors.
CNS Neurol Disord Drug Targets 13: 1520-1529, 2014.